Mehrdad Rahmaniyan M.D. US Address:

Address in Germany: C/O Mojgan Rahmaniyan M.D.

24 G, GNEISENAU Str. Dept. of Nutrition Sciences

Wurzburg , 97074, Germany Webb-248, 1675 University Blvd.

Tel. 011-49-1705014714 Birmingham, AL, 35294-3360

Email: rmehrdad@hotmail.com Tel. (205) 934-5558

Email: rahmanim@shrp.uab.edu

Career Objective:

To engage in clinical or laboratory research in the fields of Human Genetics, Biochemistry, Neuroscince, Pharmacology and Pathology.

Special Interests:

Cytogenetics, Immunogenetics, Molecular Genetics and Oncological Genetics. Particular interest in Molecular pathology of Human Carcinogenesis and Oncogenesis.

Experience:

Institute of Human Genetics, University of Wuerzburg, Wuerzburg, Germany, Aug. 98 – Present.

Education:

· Doctor of Medicine (MD), Dept. of Medicine, University of Wuerzburg, Wuerzburg, Germany, 1999.

· Internship 1997 - 1999.

· Clinical Lectures and Clerkship 1994 - 1996.

· Pre Clinical Sciences 1993 – 1994.

· Physikum ( Pre Medical/ Pre Clinical Sciences), Dept. of Medicine, University of Wuerzburg, Wuerzburg, Germany, 1990- 1993.

· Feststellungsprüfung (Premedical Basic Sciences), University College of the University of Munich, Munich, Germany, 1989 – 1990.

· Basic Sciences, University College of the University of Karlsruhe, Karlsruhe , Germany, 1989.

Relevant Courses:

· Biology, Organic Chemistry, Biostatistics

· Principles of Human Genetics including Population Genetics, Genetic Counseling and clinical rotations in the Institute of Human Genetics

· Laboratory skills including Molecular and Cytogenetic techniques such as PCR , Southern Blott, Cell Culture, Dilute Plating and DNA isolation from cultured cells

Honors/Awards:

On dean’s list during the entire pre medical, pre clinical and clinical training with GPAs close to full mark.

Research / Publication:

· Dissertations in Human Genetics, Institute of Human Genetics, University of Wuerzburg, Wuerzburg, Germany, August 1998- present

· A true hermaphrodite chimera with 46,XX and 46,XY Karyotypes with ambiguous genitalia.

We described whole-body chimerism in a newborn infant with small phallus, pseudo-vaginal perineal hypospadias and a bifid scrotum containing gonads. Chromosom

analysis in peripheral blood lymphocytes and cultured fibroblasts were performed. Dilute plating technique and Southern blott with isolated DNA from cell clons were

performed. The results showed that our patient was a chimera, with two cell lines, 46,XX in 80% and 46,XY in 20%. The findings suggested that the mechanism of chimera in this case was the fusion of two embryos. To our knowledge southern blott technique has not been used previously to detect of chimera.

A paper is currently being prepared for publishing on this project.

· Molecular genetic analysis on patients with spinal muscular atrophy using PCR to determine the mutation in the gene.

· One Model of SMA pathogenesis shows an inappropriate persistence of normally occurring motor neuron apoptosis. The NAIP gene was mapped to the SMA region of chromosome 5q13.1. The PCR analysis of 50 patients showed that the 2 first coding exons of NAIP gene are deleted in 67% of type I SMA chromosomes with compared with 2% of non-SMA chromosomes. The findings suggested that mutations in the NAIP locus might lead to failure of a normally occurring inhibition of motor neuron apoptosis resulting in or contributing to the SMA phenotype.

Availability:

Immediately.

Personal:

Single male.

Languages:

German, English, Persian, Arabic.

References:

· Prof. Dr. Med. Holger Hoehn. Director of Institute of Human Genetics, University of Wuerzburg, Wuerzburg, Germany. Tel 011-49-931-888-4070.

· Prof. Dr. med. Meulen, Dean, Faculty of Medicine, University of Wuerzburg, Germany

· Prof. Dr. med. Patzelt. Director of Department of Forensic Medicine, university of Wuerzburg, Germany